| Synthesis and properties of C–F in organic chemistry |
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Stereoelectronic effects Conformational effects Stereoselective synthesis of C–F bonds |
Our research has a strong focus on organo-fluorine chemistry, and particularly organo-fluorine chemistry focused on bioorganic and chemical biology research. We are interested in the influence of the fluorine atom on the conformation and behaviour of biomolecules.
This program benefits significantly from small molecule X-ray crystallography with Prof. Alexandra Slawin at St Andrews.
| Multivicinal Fluorine Motifs |
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Effect of multiple fluorines on aliphatic chains and rings Liquid Crystal applications |
We have a strong interest in synthetic organic chemistry and we are focussing on the synthesis of new motifs in organofluorine chemistry which can be used in a variety of performance molecules.
| Fluorine in Biology |
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Fluorometabolite biosynthesis and enzymology 18F PET Chemistry |
We also have a strong interest in enzymatic fluorination (the fluorinase) and how that can be applied to biotechnological solutions, through molecular biology, towards the production of organisms that can produce organofluorine compounds by fermentation (eg. antibiotics)