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Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols.
Oluwayinka O. Oke, Yawen Chen, Chukwuemeka Isanbor, Olayinka T. Asekun and David O’Hagan
Biocatal. Biotrans., 2023, in press

O3’-β-Glucosyl- 4’, 5’-didehydro-5’-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus.
Xuan Feng, Qingzhi Zhang, David J. Clarke, Hai Deng, David O’Hagan
J. Nat. Prod., 2023, 86, in press

Aryl tert-(β,β’,β’’-trifluoro)butyl; a candidate motif for bioactives discovery
Luca S. Dobson, Qingzhi Zhang,Benjamin McKay,Oluwayinka Oke, Chukwuemeka Isanbor, Mohd Faheem Khan, Bruno A. Piscelli, David B. Cordes,Rodrigo A. Cormanich,Cormac D. Murphy and David O’Hagan
Org. Lett., 2023, in press

Direct syntheses of stereoisomers of 3-fluoro GABA and b-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendilines and NPS R-467
Yohann J. G. Renault, Jiayin Diao, David B Cordes, Katie Leach and David O’Hagan

Med. Chem. Res., 2023, in press

Future Challenges and Opportunities with Fluorine in Drugs?
David O’Hagan and Robert J. Young

Med. Chem. Res., 2023, in press

Lateral dipole moments induced by all-cis-pentafluorocyclohexyl groups cause unanticipated effects in self-assembled monolayers.
Christian Fischer, Saunak Das, Qingzhi Zhang, Yangbiao Liu, Lothar Weinhardt, David O’Hagan, Michael Zharnikov and Andreas Terfort

Nano Res., 2023, in press

(3-Methoxy-5-(methoxy­carbonyl)­isoxazol-4-yl)(4-methoxy­phenyl)­iodonium 2,2,2-tri­fluoro­acetate.
Mohd Abdul Fatah Abdul Manan, David B. Cordes, Alexandra M. Z. Slawin and David O’Hagan

IUCrData., 2023, 8, x230300.

The emergence and properties of selectively fluorinated ‘Janus’ cyclohexanes.
David O’Hagan

Chem. Rec., 2023

Identification of genes essential for fluorination and sulfamylation within the nucleocidin gene clusters of Streptomyces calvus and Streptomyces virens
Marta Wojnowska, Xuan Feng, Yawen Chen, Hai Deng and David O’Hagan

ChemBioChem., 2023

The contribution of hyperconjugation and inductive effects to the pseudo-anomeric effect in 4-substituted methoxycyclohexanes
Bruno Piscelli, David O’Hagan and Rodrigo Cormanich

J. Phys. Chem., 2023

Does perdeuteration increase the polarity of Janus face cycloalkanes?
Zeguo Fang, Cihang Yu, Michael Bühl and David O’Hagan

Helv Chim Acta., 2023

4’-Fluoro-nucleosides and nucleotides: From nucleocidin to an emerging class of therapeutics
Phillip T. Lowe and David O’Hagan

Chem Soc. Rev., 2023, 252, 248-276

Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes.
Cihang Yu, Bruno A. Piscelli, Nawaf Al Maharik, David B. Cordes, Alexandra M. Z. Slawin, Rodrigo A. Cormanich, David O’Hagan

Chem. Commun., 2022, 58, 12855 – 12858

Janus faced fluorocyclohexanes for supramolecular assembly: Synthesis and solid state structures of equatorial mono-, di- and tri alkylated cyclohexanes and with tri-axial C-F bonds to impart polarity.
Thomas J. Poskin, Bruno A. Piscelli, Keigo Yoshida, David B. Cordes, Alexandra M. Z. Slawin, Rodrigo A. Cormanich, Shigeyuki Yamada and David O’Hagan

Chem. Commun., 2022, 58, 7968-7971

Selectively Fluorinated Citronellol Analogues Support a Hydrogen Bonding Donor Interaction with the Human OR1A1 Olfactory Receptor
Mengfan He, Weihong Liu, Chen Zhang, Yingjian Liu, Hanyi Zhuang, David O’Hagan

Org. Lett., 2022, 24, 24, 4415–4420

Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro
Tiia Kittilä, Patricia Calero, Folmer Fredslund, Phillip T. Lowe, David Tezé, Manuel Nieto-Domínguez, David O’Hagan, Pablo I. Nikel, Ditte H. Welner

Microb Biotechnol., 2022, 15, 1622–1632

Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4′-fluoroadenosine is identified as a co-product
Yawen Chen, Qingzhi Zhang, Xuan Feng, Marta Wojnowska, David O’Hagan

Org. Biomol. Chem., 2021, 19, 10081-10084

Janus all-cis 2,3,4,5,6-pentafluorocyclohexyl building blocks applied to medicinal chemistry and bioactives discovery chemistry
Joshua L. Clark, Rifahath M. Neyyappadath, Cihang Yu, Alexandra M. Z. Slawin, David B. Cordes, David O’Hagan

Chem. Eur. J., 2021, 17, 16000-16005

Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs
Joshua L. Clark, Alaric Taylor, Ailsa Geddis, Rifahath M. Neyyappadath, Bruno A. Piscelli, Cihang Yu, David B. Cordes, Alexandra M. Z. Slawin, Rodrigo A. Cormanich, Stefan Guldin, David O’Hagan

Chem. Sci., 2021, 12, 9712-9719

Effect of fluoroalkyl-substituent in bistolane-based photoluminescence liquid crystals on their physical behaviour
Shigeyuki Yamada, Masato Morita, Yizhou Wang, Qingzhi Zhang, David O’Hagan, Tomohiro Agou, Hiroki Fukumoto, Toshio Kubota, Mitsuo Hara. Tsutomu Konno

Crystals, 2021, 11, 450. 

The contribution of non-classical CHax∙∙∙OC hydrogen bonds to the anomeric effect in fluoro and oxa-methoxycyclohexanes
Bruno A. Piscelli, David O’Hagan, and Rodrigo A. Cormanich

PhysChemChemPhy, 2021, 23, 5845 – 5851.

Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR
Manuele Musolino, Ian N. Fleming, Lutz F. Schweiger, Prof. Dr. David O’Hagan, Sergio Dall’Angelo and Matteo Zanda

Eur. J. Org. Chem., 2021, 1429–1439

Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
Xuan Feng, Davide Bello and David O’Hagan

RSC Adv., 2021,11, 5291-5294

A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
Patricia Calero, Daniel C. Volke, Phillip T. Lowe, Charlotte H. Gotfredsen, David O’Hagan and Pablo I. Nikel

Nature Commun., 2020, 11, 5045

Next generation organofluorine containing blockbuster drugs
Jianlin Han, Attila Márió Remete, Luca S. Dobson, Lorand Kiss, Kunisuke Izawa, Hiroki Moriwaki, Vadim A. Soloshonok and David O’Hagan

J. Fluorine Chem., 2020, 239, 109639

Janus face all-cis 1,2,4,5-tetrakis(trifluoromethyl)- and all-cis 1,2,3,4,5,6-hexakis(trifluoromethyl)- cyclohexanes
Cihang Yu, Agnes Kütt, Gerd-Volker Röschenthaler, Tomas Lebl, David B. Cordes, Alexandra M. Z. Slawin, Michael Bűhl and David O’Hagan

Angewandte Chemie. Int. Ed., 2020, 59, 19905 –19909

Fluorine induced pseudo-anomeric effects in methoxycyclohexanes through electrostatic 1,3-diaxial interactions
Zeguo Fang, Nawaf Al-Maharik, Peer Kirsch, Matthias Bremer, Alexandra M. Z. Slawin and David O’Hagan

Chem. Eur. J., 2020, 26, 11989–11994

Synthesis of organic liquid crystal containing selectively fluorinated cyclopropanes
Zeguo Fang, Nawaf Al-Maharik, Peer Kirsch, Matthias Bremer, Alexandra M. Z. Slawin and David O’Hagan

Beilstein J. Org. Chem., 2020, 16, 674-680.

Polar organofluorine substituents: Placing fluorines along alkyl chains and around alicyclic rings
David O’Hagan

Chem. Eur. J., 2020, 26, 7981-7997.

An engineered E. coli strain for direct in vivo fluorination
Konstantinos Markakis, Phillip T. Lowe, Liam Davison-Gates, David O’Hagan, Susan J.Rosser and Alistair Elfick

ChemBioChem., 2020, 21,1856-1860.

Probing the helical integrity of multivicinal all-syn-fluoro alkanes
Nawaf Al-Maharik, David B. Cordes, Alexandra M. Z. Slawin, Michael Bühl and David O’Hagan

Org. Biomol. Chem., 2020,18, 878-887

A role for fluorine in flavours, fragrances and pheromones
Phillip T. Lowe and David O’Hagan

J. Fluorine Chem., 2020, 109420

Unexpected α,α’-difluoroethers from Ag(I)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene
Zeguo Fang, Roscoe Z. Gillatt, Alexandra M. Z. Slawin, David B. Cordes, Cameron L. Carpenter-Warren and David O’Hagan

Chem. Commun., 2019, 55, 14295 – 14298

Two 3’-O- β-Glucosylated Nucleoside Fluorometabolites Related to Nucleocidin in Streptomyces calvus
Xuan Feng, Davide Bello, Phillip T. Lowe, Joshua Clark and David O’Hagan

Chem. Sci., 2019, 10, 9501 – 9505

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif
Zeguo Fang, David B. Cordes, Alexandra M. Z. Slawin and David O’Hagan

Chem. Commun., 2019, 55, 10539 – 10542

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange
Phillip T. Lowe, Stephen L. Cobb and David O’Hagan

Org. Biomol. Chem., 2019, 17, 7493 – 7496

Fluorine containing substituents: metabolism of the α,α-difluoroethyl thioether motif
Andrea Rodil, Alexandra M. Z. Slawin, Nawaf Al-Maharik, Ren Tomita and David O’Hagan

Beilstein J. Org. Chem.., 2019, 15, 1441-1447

Fluorine in pheromones: Synthesis of fluorinated 12-dodecanolides as Emerald Ash Borer pheromone mimetics
Qingzhi Zhang, Charlotte S. Teschers, Ricardo Callejo, Mingyan Yang, Mingan Wang, Peter J. Silk, Krista Ryall, Lucas E. Roscoe, David B Cordes, Alexandra M. Z. Slawin and David O’Hagan

Tetrahedron., 2019, 7, 2917-2922.

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys-based ligand for the prostate-specific membrane antigen (PSMA)
Phillip T. Lowe, Sergio Dall’Angelo, Ian N. Fleming, Monica Piras, Matteo Zanda and David O’Hagan

Org. Biomol. Chem., 2019, 17, 1480 – 1486

The St Andrews periodic table
David O’Hagan, M Pilar Gil and R A. Aitken,

Chemistry World, 2019, 16 (2), 68-69.

Acetyl coenzyme A analogues as rationally designed inhibitors of citrate synthase.
Davide Bello, Maria Grazia Rubanu, Nouchali Bandaranayaka, Jan. P. Götze, Michael Bühl, David O’Hagan

ChemBioChem, 2019, 20, 1174-1182.