Dr Neil Keddie

Dr Neil Keddie studied for his MChem in Chemistry with Medicinal Chemistry at the University of St Andrews, spending his industrial year at Organon Laboratories, Newhouse (2003–04).  He then remained at St Andrews to conduct his PhD studies with Dr Stuart Conway (now University of Oxford) from 2005–2008, finishing his lab based work at the University of Oxford in early 2009.  In November 2009 he was awarded a PhD for a thesis on “The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands”.

In October 2009 he begun work as a Postdoctoral Researcher in the O’Hagan group, examining the synthesis of multivicinal fluorinated cyclohexane rings.  His work is supported by the EPSRC.  In September 2014, Neil began additional teaching fellow work in addition to his ongoing research in the lab.  In August 2018, Neil left the group to take up a new post as an Associate Lecturer (Education Focused) at St Andrews.

In his spare time, Neil enjoys spending time with his wife and three children, DIY on his house renovation project (a long running affair) and walking his dog.

My Publications

Stereochemical outcomes of C–F activation reactions of benzyl fluoride
Neil S. Keddie, Pier Alexandre Champagne, Justine Desroches, Jean-François Paquin and David O’Hagan

Beilstein J. Org. Chem., 2018, 14, 106–113.

The Interaction of B12F122− with all-cis 1, 2, 3, 4, 5, 6-Hexafluorocyclohexane in the Gas Phase
Michael J. Lecours, Rick A. Marta, Vincent Steinmetz, Neil S. Keddie, Eric Fillion, David O’Hagan, Terrance B. McMahon, William Scott Hopkins

J. Phys. Chem. Lett., 2017, 8, 109–113

Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase
Blake E. Ziegler, Michael Lecours,  Rick A. Marta, Joshua Featherstone, Eric Fillion, W. Scott Hopkins, Vincent Steinmetz, Neil S. Keddie, David O’Hagan and Terrance B. McMahon

J. Am. Chem. Soc., 2016, 138, 7460–7463

Highlighted in:

Particularly strong C–H···π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane
Rodrigo A. Cormanich, Neil Keddie, Roberto Rittner, David O’Hagan and Michael Bühl

Phys. Chem. Chem. Phys., 2015, 44, 29475–29478

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane
Neil S. Keddie, Alexandra M. Z. Slawin, Tomas Lebl, Douglas Philp and David O'Hagan

Nature Chemistry, 2015, 7, 483–488.

Highlighted in:
Nature Chemistry News and Views (10.1038/nchem.2240)
RSC Chemistry World

Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK
Amy Weeks, Neil Keddie, Rudy Wadoux, David  O’Hagan, Michelle Chang

Biochemistry, 2014, 53, 2053–2063.

Chiral fluoroacetate: Synthesis of (R)- and (S)- [2H1]-fluoroacetate in high enantiopurity
Rudy Wadoux,  Xiaowei Lin,  Neil Keddie and David O’Hagan

Tetrahedron: Asymmetry, 2013, 214, 719–723.